3-Methoxy-4-o-tolylureidophenylacetic acid → HCID 20610294, compound

HRID 433684Notes

Reaction equation

HRID 433684 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:20][C:21]([OH:23])=O)[CH:6]=[CH:7][C:8]=1[NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=[O:11].Cl.[CH3:25][O:26][C:27](=[O:52])[CH:28]([NH:41][C:42](=[O:51])[C:43]1[C:48]([Cl:49])=[CH:47][CH:46]=[CH:45][C:44]=1[Cl:50])[CH2:29][C:30]1[O:34][N:33]=[C:32]([CH:35]([NH2:40])[CH2:36][CH:37]([CH3:39])[CH3:38])[CH:31]=1>>[CH3:25][O:26][C:27](=[O:52])[CH:28]([NH:41][C:42](=[O:51])[C:43]1[C:44]([Cl:50])=[CH:45][CH:46]=[CH:47][C:48]=1[Cl:49])[CH2:29][C:30]1[O:34][N:33]=[C:32]([CH:35]([NH:40][C:21](=[O:23])[CH2:20][C:5]2[CH:6]=[CH:7][C:8]([NH:9][C:10]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])=[O:11])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:36][CH:37]([CH3:39])[CH3:38])[CH:31]=1

Participants

3

Reactant 2

HCID 114498403-Methoxy-4-o-tolylureidophenylacetic acidHCID 69735661HCID 69735661, compound

Product 1

HCID 20610294HCID 20610294, compoundYield 51%

Procedure

The title compound was prepared in the manner described in example 2B using 3-methoxy-4-(3-o-tolyl-ureido)-phenylacetic acid and 3-[3-(1-amino-3-methyl-butyl)-isoxazol-5-yl]-2-(2,6-dichloro-benzoylamino)-propionic acid methyl ester hydrochloride. 51% yield; white solid. MS (m/z) 724.2 and 726.2 (M+1).

Sources & evidence

ORD record
ord-05fa9dc30a4843ff9c40392bebc0ca98
Source dataset
uspto-grants-2003_12
Patent number
US06667331B2

Reaction notes

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