HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (4-Isopropylthiazol-2-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl 4-propan-2-yl-1,3-thiazole-2-carboxylate | HCID 18759001 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (4-Isopropylthiazol-2-yl)methanol | HCID 10678505 | 5% |
Reaction Steps
Using the procedure of Example 5B, but replacing ethyl 2-isopropyl-4-thiazolecarboxylate with methyl 4-isopropylthiazole-2-carboxylate provided, after silica gel chromatography using 2% methanol in chloroform, the desired compound (Rf 0.3, 5% methanol in chloroform) in 96% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667404B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-0c85b1ce984f45cbbe6ad6f290b893bd |
| Source note | uspto-grants-2003_12 |