HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Ethyl 2-isopropylthiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Methylpropanethioamide | HCID 10909507 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Ethyl 2-isopropylthiazole-5-carboxylate | HCID 10608068 | 83% |
Reaction Steps
Using the procedure of Example 1J but replacing thioformamide with 2-methylpropane-thioamide provided, after silica gel chromatography using 9:1 ethyl acetate:hexane, the desired compound, Rf 0.8, (5% methanol in chloroform) in 83% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667404B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-28fd345ec9064c4cad5911637f18a5ef |
| Source note | uspto-grants-2003_12 |