HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → 2-Cyclopentyl-4-(((N-ethyl)amino)methyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 4-(Chloromethyl)-2-cyclopentylthiazole hydrochloride | HCID 18758931 | — |
| Product | 2-Cyclopentyl-4-(((N-ethyl)amino)methyl)thiazole | HCID 18759118 | — |
Reaction Steps
Using the procedure of Example 1Q, but replacing 4-(chloromethyl)-2-isopropylthiazole hydrochloride with 4-(chloromethyl)-2-cyclopentylthiazole hydrochloride and replacing 40% aqueous methylamine with 70% aqueous ethylamine provided, after purification of the residue by silica gel chromatography using 5% methanol in chloroform, 1.08 g (50%) of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06667404B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-dfe0c0ad2ac84cd983ae687ff0c75a69 |
| Source note | uspto-grants-2003_12 |