Methyl 2,2-dimethylpent-4-ynoate → 3-[3-(1-tert-Butoxycarbonylamino-3-methyl-butyl)-isoxazol-5-yl]-2,2-dimethyl-propionic acid methyl ester

HRID 433832Notes

Reaction equation

HRID 433832 reaction equation
[C:1]([O:5][C:6](=[O:16])[NH:7][CH:8]([CH:13]=[N:14][OH:15])[CH2:9][CH:10]([CH3:12])[CH3:11])([CH3:4])([CH3:3])[CH3:2].[CH3:17][O:18][C:19](=[O:26])[C:20]([CH3:25])([CH3:24])[CH2:21][C:22]#[CH:23]>>[CH3:17][O:18][C:19](=[O:26])[C:20]([CH3:25])([CH3:24])[CH2:21][C:22]1[O:15][N:14]=[C:13]([CH:8]([NH:7][C:6]([O:5][C:1]([CH3:3])([CH3:2])[CH3:4])=[O:16])[CH2:9][CH:10]([CH3:12])[CH3:11])[CH:23]=1

Participants

3

Reactant 2

HCID 13134461Methyl 2,2-dimethylpent-4-ynoateHCID 73685451[1-(Hydroxyimino-methyl)-3-methyl-butyl]-carbamic acid tert-butyl ester

Product 1

HCID 206102983-[3-(1-tert-Butoxycarbonylamino-3-methyl-butyl)-isoxazol-5-yl]-2,2-dimethyl-propionic acid methyl ester

Procedure

Prepared from [1-(hydroxyimino-methyl)-3-methyl-butyl]-carbamic acid tert-butyl ester (7I) and 2,2-dimethyl-pent-4-ynoic acid methyl ester according to the procedure outlined in example 6A. MS (CI) m/z: 313.2 (M-tBu), 269.3 (M−99)

Sources & evidence

ORD record
ord-86032b9c46784200b02f345fb2f7bb57
Source dataset
uspto-grants-2003_12
Patent number
US06668527B2

Reaction notes

Loading…