Oleic Acid → HCID 86591822, compound
Reaction equation
[C:1]([OH:20])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>C(O)C>[CH2:1]([OH:19])[CH3:2].[C:1]([OH:20])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]Participants
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 37 °C
Procedure
Three hundred mg of hydroxypropyl cellulose was dispersed in 7.7 mL of ethanol and heated with occasional stirring to 37° C. for 24 hours, then cooled to room temperature. The resultant gel was mixed with 1 mL of oleic acid via syringe-to-syringe transfer 30 times through a connecting Luer mixing adapter to produce a bulk ethanol/oleic acid gel. A solution or suspension of the cytotoxic drug in ethanol was prepared by combining the appropriate weight of drug (see Table 1) with 1 mL of ethanol and dispersing/dissolving by mixing vigorously and/or sonicating. Finally, 0.9 mL of bulk ethanol/oleic acid gel was mixed with 0.1 mL of cytotoxic drug solution or suspension by syringe-to-syringe transfer 30 times through a connecting Luer mixing adaper to produce the final gel.
Workup
- temperatureheated
- temperaturecooled to room temperature
- additionmixing adapter
Sources & evidence
- ORD record
- ord-873cbe783cb94990a0c427914620365f
- Source dataset
- uspto-grants-2003_12
- Patent number
- US06669958B1
Reaction notes
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