Hydrochloric Acid → HCID 13811966, compound

Participants

Reaction Steps

1.1 g, (4.9 mmol) 15 was added to 1.15 g (14.6 mmol) distilled pyridine in 30 mL dry benzene with stirring, followed by 1.8 g (14.6 mmol) thionyl chloride. The mixture was heated to reflux for 6 hours. After cooling in an ice bath, 5 mL 3M HCl was added with vigorous stirring. The organic layer was separated, washed 3× with a dilute brine solution, and dried (MgSO4) to yield a yellowish oil. After washing and removal of solvent, the dichloride was used without further purification.

Provenance & Evidence