Sodium Methoxide → HCID 10230712, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[6-chloro-5-(2-methoxyphenoxy)-2-(3-pyridazinyl )-4-pyrimidinyl]-2-(1-naphthyl)ethanesulfonamide (0.088 g, 0.17 mmol) (Preparation 14) in methanol (5 ml) was added sodium methoxide (25% w/v in methanol, 1.0 ml). The mixture was stirred vigorously for 72 hours at 60° C. and then quenched with aqueous hydrochloric acid (2 M, 1 ml). Ice-cold water (2 ml) was added and a white precipitate formed. The resultant mixture was partitioned between water (5 ml) and dichloromethane (3×10 ml). The combined organic extracts were washed with water (3×10 ml), dried (magnesium sulfate) and concentrated under vacuum to give the title compound as a yellow solid (95% pure by HPLC). (0.065 g).

Provenance & Evidence