反应详情

温度

50 °C

A mixture of fluorobenzene (181 mL) and aluminum chloride (18.5 g, 139 mmol) was treated with a solution of 4-methylthiophenyl acetic chloride (21.9 g, 120 mmol) in 37 mL of fluorobenzene. When the addition was completed, the mixture was stirred at 50° C. for 3 h. The reaction mixture was then poured into ice water and stirred for 1 h. It was extracted with chloroform and washed with 5% aqueous sodium bicarbonate solution and with brine. The organic layer was separated and dried over anhydrous sodium sulfate. The drying agent was filtered and the filtrate concentrated in vacuum to give 15.6 g (55%) of the desired compound as a yellow solid.

1. additionWhen the addition
2. stirringstirred for 1 h
3. extractionIt was extracted with chloroform
4. washwashed with 5% aqueous sodium bicarbonate solution and with brine
5. customThe organic layer was separated
6. dry with materialdried over anhydrous sodium sulfate
7. filtrationThe drying agent was filtered
8. concentrationthe filtrate concentrated in vacuum