反应详情

A mixture of 1-(4-fluorophenyl)-2-(4-methylsulfonyl phenyl)ethanone (14.6 g, 50 mmol) in 210 mL of chloroform and 826 mL of CCl4. A solution of 8.0 g (50 mmol) of bromine in CCl4 was added dropwise to the mixture. When the loss of the bromine colour was complete, the organic layer was washed with 5% aqueous sodium bicarbonate solution and with brine. It was dried over anhydrous sodium sulfate. The drying agent was filtered, and the filtrate concentrated in vacuum to give 14.0 g (70%) of the desired product as a solid.

1. washthe organic layer was washed with 5% aqueous sodium bicarbonate solution and with brine
2. dry with materialIt was dried over anhydrous sodium sulfate
3. filtrationThe drying agent was filtered
4. concentrationthe filtrate concentrated in vacuum