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3,4-Dimethoxyphenethyl alcohol → Methyl 2-Hydroxy-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-Dimethoxyphenethyl alcohol | HCID 81911 | — |
| 反応物 | Methyl 3,3-diphenyloxirane-2-carboxylate | HCID 10587027 | — |
| 触媒 | Boron trifluoride etherate | HCID 8000 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 2-Hydroxy-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionate | HCID 18756198 | — |
反応手順
7 g (27.5 mmol) of methyl 3,3-diphenyl-2,3-epoxypropionate and 5.5 g (30.2 mmol) of 2-(3,4-dimethoxyphenyl)ethanol were dissolved in 20 ml of dichloromethane and, at room temperature, 5 drops of boron trifluoride etherate were added. The solution was stirred for 2 hours. The solvent was then distilled off, and the residue (10.7 g, 89%) was immediately reacted further.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06670367B1 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-25a8cc06e044439baf8afa2a89b389b2 |
| 出典メモ | uspto-grants-2003_12 |