反应详情

温度

80 °C

12 g (27.5 mmol) of methyl 2-hydroxy-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionate were dissolved in 110 ml of dioxane, and 55 ml of 1 N NaOH solution were added. The mixture was stirred at 80° C. for 2 hours. Water was added to the mixture, and the aqueous phase was extracted twice with ether. The aqueous phase was acidified with 1 N aqueous HCl and extracted with ether, the organic phase was dried over magnesium sulfate, and the solvent was distilled off. The residue was recrystallized from ether/n-hexane, and 10.2 g (87%) of colorless crystals were isolated.

1. extractionthe aqueous phase was extracted twice with ether
2. extractionextracted with ether
3. dry with materialthe organic phase was dried over magnesium sulfate
4. distillationthe solvent was distilled off
5. customThe residue was recrystallized from ether/n-hexane