HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(2,6-Difluorophenyl)-5-methylisoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-(2,6-difluorophenyl)-5-methylisoxazole-4-carboxylate | HCID 18756257 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(2,6-Difluorophenyl)-5-methylisoxazole-4-carboxylic acid | HCID 18756250 | 99.2% |
Reaction Steps
In a manner similar to that for preparation 16, 4-methoxycarbonyl-5-methyl-3-(2,6-difluorophenyl)isoxazole (0.244 g, 0.910 mmol), 5N NaOH (1 ml, 5.0 mmol), and methanol (10 ml) afforded 4-carboxy-5-methyl-3-(2,6-difluorophenyl)isoxazole (0.216 g, 93%) which was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06670373B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-3a3eede7160c4df49d472115bd8a1b3b |
| Source note | uspto-grants-2003_12 |