HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 4-Bromo-2-fluoro-N-hydroxybenzenecarboximidoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 4-Bromo-2-fluorobenzaldehyde oxime | HCID 2773325 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-2-fluoro-N-hydroxybenzenecarboximidoyl chloride | HCID 73461925 | 81.4% |
Reaction Steps
In a fashion similar to that for preparation 14, 2-Fluoro-4-bromo-benzaldehyde oxime (2.77 g, 12.7 mmol), N-chlorosuccinimide (1.76 g, 13.2 mmol), and DMF (25 ml) gave 2-fluoro-4-bromo-benzoyl chloride oxime (2.61 g, 81%) after filtration through a plug of silica gel eluting with hexanes/Et2O.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06670373B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-75de2550fe8440dca69b4457c541a5f2 |
| Source note | uspto-grants-2003_12 |