HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-Carboxy-5-methyl-3-(2-fluoro-4-bromophenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 3-(4-bromo-2-fluorophenyl)-5-methylisoxazole-4-carboxylate | HCID 18756263 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Carboxy-5-methyl-3-(2-fluoro-4-bromophenyl)isoxazole | HCID 18756285 | 100.6% |
Reaction Steps
In a fashion similar to that described for preparation 16 (120 mg), 4-ethoxycarbonyl-5-methyl-3-(2-fluoro-4-bromophenyl)isoxazole (350 mg, 1.06 mmol), 5N NaOH (1 ml, 5 mmol), methanol (5 ml), and THF (1 ml) gave 4-carboxy-5-methyl-3-(2-fluoro-4-bromophenyl)isoxazole (320 mg, 100%) that was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06670373B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-23a7f48b2f134449bd58e0bdc466625e |
| Source note | uspto-grants-2003_12 |