Sodium Hydroxide → HCID 22714140, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-ethoxycarbonyl-5-methyl-3-(2-fluoro-5-iodophenyl)isoxazole (1.04 g, 2.77 mmol) in EtOH (14 ml) was added 5N NaOH (1.11 ml, 5.6 mmol, 2 eq.) and stirred in a 50° C. oil bath for 1 hr. Rxn was cooled to room temperature, poured into ice H2O and extracted with Et2O. Acidified aqueous layer to pH 2 using conc. HCl and extracted with ethyl acetate. The combined organic solution was washed with brine, dried (MgSO4), filtered, and concentrated to give the title compound (0.85 g, 86%).

Provenance & Evidence