Hydrochloric Acid → HCID 54696989, compound

Participants

Reaction Steps

25 ml of ethanol was added to 3.64 g (0.01 mol) of 3-hexyloxy-4-hydroxy-5-ethoxycarbonylmethoxy-2H-1-benzopyran-2-one, and 25 ml of an aqueous 1 mol/L sodium hydroxide solution was added under ice cooling, followed by continuous stirring at room temperature for 4 hours. The reaction solution was added to 26 ml of hydrochloric acid having a concentration of 1 mol/L, and after extracting twice with 50 ml of ethyl acetate, the extract was dried over magnesium sulfate. After filtering the ethyl acetate solution, the filtrate was concentrated under reduced pressure, and the resulting crude product was recrystallized from methanol to obtain 2.4 g of the titled compound (yield: 74%)

Provenance & Evidence