Triethylamine → HCID 68809404, compound

Participants

Reaction Steps

To a solution of ((R)-1-(4-amino-benzyl)-2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-ethyl)-carbamic acid tert-butyl ester (1.19 g, 2.61 mmol) in dichloromethane (15 ml) cooled to 0° C. is added triethylamine (0.37 ml, 2.65 mmol) and methanesulfonylchloride (0.192 ml, 2.49mmol). The reaction mixture is allowed to warm to ambient temperature with stirring for 1 hour, then washed with water and saturated brine solution, dried over magnesium sulphate and evaporated. The crude product is purified by flash silica chromatography (ethylacetate:hexane gradient 6:4 to 1:0 elution) to afford [(R)-2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-1-(4-methanesulfonylamino-benzyl)-ethyl]-carbamic acid tert-butyl ester. [MH]+534.7.

Provenance & Evidence