4-Methoxybenzenesulfonyl chloride → HCID 70455624, compound

HRID 434350Notes

Reaction equation

HRID 434350 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([Cl:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[NH2:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1.S(Cl)(Cl)(=O)=O>[OH-].[Na+]>[Cl-:12].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:13][CH2:14][CH2:15][CH2:16][NH+:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 24648Sulfuryl chlorideHCID 316701-Pyrrolidinepropanamine

Product 1

HCID 70455624HCID 70455624, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-Methoxybenzenesulphonylchloride (8.26 g, 0.04 mol) was added in portions with stirring to a solution of 1-(3-aminopropyl)-pyrrolidine (5.13 g, 0.04 mol) in 10% NaOH (100 ml), and the resulting mixture was stirred at room temperature for the next 24 hours. Unreacted sulphonylchloride was filtered off, and the filtrate was adjusted to pH 9,8 with dilute HCl.

Workup

  1. filtrationwas filtered off

Sources & evidence

ORD record
ord-31e236959e3e4a63b231d7a798ec0f80
Source dataset
uspto-grants-1983_08
Patent number
US04396622

Reaction notes

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