4-Iodobenzenesulfonyl chloride → 2,4-Dimethyl-1-[3-(4-iodobenzenesulphonamido)propyl]pyrrolidine

HRID 434351Notes

Reaction equation

HRID 434351 reaction equation
[CH3:1][CH:2]1[CH2:6][CH:5]([CH3:7])[CH2:4][N:3]1[CH2:8][CH2:9][CH2:10][NH2:11].[I:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>C1C=CC=CC=1>[CH3:1][CH:2]1[CH2:6][CH:5]([CH3:7])[CH2:4][N:3]1[CH2:8][CH2:9][CH2:10][NH:11][S:19]([C:16]1[CH:17]=[CH:18][C:13]([I:12])=[CH:14][CH:15]=1)(=[O:21])=[O:20]

Participants

4

Reactant 2

HCID 73994-Iodobenzenesulfonyl chlorideHCID 202277352,4-Dimethyl-1-(3-aminopropyl)pyrrolidine

Product 1

HCID 202277342,4-Dimethyl-1-[3-(4-iodobenzenesulphonamido)propyl]pyrrolidine

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 2,4-dimethyl-1-(3-aminopropyl)pyrrolidine (4.7 g, 0.03 mol) in benzene (20 ml) was added dropwise to a solution of 4-iodobenzenesulphonylchloride (9.1 g, 0.03 mol) benzene (80 ml). After stirring the resulting mixture for six hours at room temperature, the reaction product separated as an oil. The reaction mixture was evaporated, and the residue was dissolved in absolute alcohol (800 ml) and boiled with charcoal.

Workup

  1. customthe reaction product separated as an oil
  2. customThe reaction mixture was evaporated
  3. dissolutionthe residue was dissolved in absolute alcohol (800 ml)

Sources & evidence

ORD record
ord-6c2bfe006d9349379f44111050ce82f0
Source dataset
uspto-grants-1983_08
Patent number
US04396622

Reaction notes

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