Acetyl chloride → HCID 23322169, compound

HRID 434369Notes

Reaction equation

HRID 434369 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].C1[O:19][C:8]([CH3:18])([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=2)OC1>CCOCC>[C:1]([O:17][CH2:16][C:13]1[CH:12]=[CH:11][C:10]([CH2:9][C:8](=[O:19])[CH3:18])=[CH:15][CH:14]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 20273625{4-[(2-Methyl-1,3-dioxolan-2-yl)methyl]phenyl}methanol

Product 1

HCID 23322169HCID 23322169, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Acetyl chloride (5.0 ml) in dry ether (20 ml) was added dropwise to a stirred solution of 1-(4-hydroxymethylphenyl)propane-2-one ethylene ketal (3.0 g) (as prepared in description 1) in dry ether (50 ml). The mixture was refluxed for 1 h, evaporated and deketalised as described in description 1, to give the title compound as a colourless oil which was bulb distilled, bath temperature 120°-130°/o. 1 mm Hg.

Workup

  1. temperatureThe mixture was refluxed for 1 h
  2. customevaporated

Sources & evidence

ORD record
ord-60a4ffbef74c4fd582cb266b82d0d517
Source dataset
uspto-grants-1983_08
Patent number
US04396627

Reaction notes

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