Chloroform → N-propylamino-3-chloro propane hydrochloride

There was added to about 124 parts of the above N-propyl-3-amino propanol dissolved in 1194 parts of chloroform under an atmosphere of nitrogen and at a temperature of about 0° C., 189 parts of thionyl chloride at a rate which was sufficient to maintain the temperature of the resulting reaction mixture below 20° C. When the addition was complete, the solution was brought to reflux for 30 minutes. The reaction mixture was then quenched with excess ethanol and concentrated to provide a yellow viscous oil. There was obtained a quantitative yield of N-propylamino-3-chloro propane hydrochloride after the aforementioned yellow viscous oil was crystallized from ethanol in the form of a white crystalline solid; (M.P. 246°-247° C.).

1. temperatureto maintain
2. customthe temperature of the resulting reaction mixture below 20° C
3. additionWhen the addition
4. temperatureto reflux for 30 minutes
5. customThe reaction mixture was then quenched with excess ethanol
6. concentrationconcentrated
7. customto provide a yellow viscous oil

ORD record

ord-fa9e4ad6765444948d2c818245acd2d3

Source dataset

uspto-grants-1983_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04396728