Ethylene Glycol → N-ethyl-N-1,3-dioxolan-2-ylmethyl-2,6-dinitro-p-toluidine

Participants

Reaction Conditions

Reaction Steps

N-Ethyl-N-(2,2-diethoxyethyl)-2,6-dinitro-p-toluidine (5.2 grams; 0.0132 mole), ethylene glycol (0.82 grams; 0.0132 mole) and toluenesulfonic acid (200 mg) were charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture was heated at 110° C. for a period of one hour. After this time the mixture was dissolved in ethyl acetate and the resulting solution washed with aqueous base, dried and stripped of solvent to yield the desired product N-ethyl-N-1,3-dioxolan-2-ylmethyl-2,6-dinitro-p-toluidine as a brown oil.

Provenance & Evidence