Hydrochloric Acid → HCID 13187242, compound

Participants

Reaction Steps

To a rapidly stirred suspension of 16 g. (140 mmol.) of potassium t-butoxide in 600 mL. of anhydrous ether was added dropwise under nitrogen 11.7 g. (35 mmol.) of ethyl ester of 3-chloro-2-[(ethoxymethylphosphinyl)methyl]benzoic acid previously prepared as in Step A of Part B above in 50 mL. of ether. The reaction mixture was stirred for an additional 30 minutes. 100 mL. of water was added followed by concentrated hydrochloric acid to provide a pH of 7. The ether layer was separated, washed with brine and concentrated. Crystallization from hexane/methylene chloride gave 7.5 g. (83% yield) of 8-chloro-2-ethoxy-2,3-dihydro-2-oxo-4(1H)-isophosphinolinone as a representative species of compounds of formula (II).

Provenance & Evidence