2-Aminothiazole → HCID 20492766, compound

Participants

Reaction Steps

A mixture of 2-ethoxycarbonyl-4-methyl-2H-1,4-benzothiazin-3(4H)one (6.22 g), 2-aminothiazole (7.43 g), and xylene (31 ml) was refluxed for 6 hours. After being cooled, the mixture was washed with 10% hydrochloric acid, water, dried over magnesium sulfate, and evaporated under reduced pressure. The residue was crystallized from diethyl ether and collected by filtration. The crude crystals were purified by recrystallization from acetonitrile to yield 1.17 g of 4-methyl-2-(2-thiazolylcarbamoyl)-2H-1,4-benzothiazin-3(4H)one.

Provenance & Evidence