4-Fluoroaniline → HCID 20492772, compound

Participants

Reaction Steps

A mixture of 2-ethoxycarbonyl-4-methyl-2H-1,4-benzothiazin-3(4H)one (2.4 g) and 4-fluoroaniline (1.59 g) was stirred for 5 hours at 180° to 185° C. After standing at room temperature, the reaction mixture was crystallized from diisopropyl ether and purified by recrystallization from diisopropyl ether to afford 0.94 g of 2-(4-fluorophenylcarbamoyl)-4-methyl-2H-1,4-benzothiazin-3(4H)one as a white crystal.

Provenance & Evidence