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In 40 ml of a mixture of chloroform and ethyl alcohol (1:1) were suspended 1.49 g (10 mmoles) of D-penicillamine and 1.89 g (15 mmoles) of N,N-dimethylacetoacetamide. The suspension was heated at 80°-90° C. with stirring under a stream of argon to concentrate to a half its volume. 20 ml of a mixture of chloroform and ethyl alcohol (1:1) was added. The concentration and addition of the solvent were repeated until the reaction mixture turned completely clear and a small amount of insolubles was removed by filtration. The solvent was distilled off, and the resulting residue was treated according to the same procedure as in Example 1 to give 1.98 g of 4-carboxy-2,5,5-trimethylthiazolidine-2-N,N-dimethylacetamide as colorless prisms.

1. temperatureThe suspension was heated at 80°-90° C.
2. concentrationto concentrate to a half its volume
3. addition20 ml of a mixture of chloroform and ethyl alcohol (1:1) was added
4. concentrationThe concentration and addition of the solvent
5. customa small amount of insolubles was removed by filtration
6. distillationThe solvent was distilled off
7. additionthe resulting residue was treated