Allyl bromide → HCID 12770911, compound

Participants

Reaction Steps

A mixture of 1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3carboxylic acid hydrochloride (0.18 g), triethylamine (0.12 g), allyl bromide (0.09 g), and DMF (3 ml) was heated with stirring at 90° for 3 hours and the solvent was evaporated. The residue was dissolved in 2N sodium hydroxide solution. The alkaline solution was adjusted to pH 7 with aqueous acetic acid and extracted with dichloromethane. The organic layer was washed with water, dried over anhydrous sodium sulfate, and evaporated. The residue was recrystallized from a mixture of DMF and ethanol to give 7-(4-allyl-1-piperazinyl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.055 g), mp 227°-230° C. (decomp.).

Provenance & Evidence