Morpholine → HCID 1505698, compound

Participants

Reaction Steps

A mixture of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.43 g), morpholine (1.4 g), and pyridine (3 ml) was refluxed for 6 hours. After the mixture evaporated to dryness, the residue was acidified with aqueous acetic acid and extracted with dichloromethane. The organic layer was washed with water, dried, and evaporated. The solid was recrystallized from a mixture of DMF and ethanol and gave 1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-morpholinyl)-4-oxoquinoline-3-carboxylic acid (0.28 g), mp 268°-271° C. (decomp.).

Provenance & Evidence