Phosphoric Acid → HCID 13386615, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of water (800 ml) and potassium dihydrogenphosphate (0.3 g) was heated to 100° C. and then adjusted to pH 5.0 with addition of phosphoric acid. 2-Furyl-2-cyclohexenylcarbinol (20 g) was then added, and the mixture was stirred under reflux for 20 hours while keeping the pH at 5.0. After addition of MgCl2.6H2O (20 g), the mixture was adjusted to pH 7.3 with an aqueous 1N NaOH solution and stirred for 8 hours under reflux. The reaction mixture was cooled, admixed with sodium chloride (20 g) and extracted with methyl isobutyl ketone. The extract was concentrated, and the residue was distilled to give 2-(2-cyclohexenyl)-4-hydroxy-2-cyclopentenone with the yield of 14.2 g (71%). B.P., 140°-145° C./1.5 mmHg.

Provenance & Evidence