反应详情

85 g of ethyl 4-bromo-2-propoxyimino-acetoacetate are added dropwise to 23 g (0.3 mole) of thiourea in 155 ccs of water and 75 ccs of ethanol at 25°, while stirring. After one hour, the hydrobromide which has precipitated in the meantime is decomposed by adding concentrated ammonia up to pH 6. After filtering off the product, washing with water and diisopropyl ether and drying, 45 g of ethyl 2-(2-aminothiazol-4-yl)-2-propoxyimino-acetate are obtained.

1. customthe hydrobromide which has precipitated in the meantime
2. additionby adding concentrated ammonia up to pH 6
3. filtrationAfter filtering off the product
4. washwashing with water and diisopropyl ether
5. customdrying