1-Amino-3-methylbutan-2-one hydrochloride → Ethyl 5-isopropyl-1H-imidazole-2-carboxylate

Participants

Reaction Steps

The same operation as in Example (lb) was performed using 1-amino-3-methylbutan-2-one hydrochloride obtained in Example (35c) (about 17.6 mmol) and ethyl imino(methylthio)acetate tetrafluoroborate obtained according to a method known in the literature (J. Med. Chem., 38, 1995, 2196-2201) (about 22 mmol), to obtain 1.83 g of the title compound as a yellow solid (57%).

Provenance & Evidence