Sodium Carbonate → HCID 20491762, compound

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of 5-chloropyrimidin-2-one (131 mg), 2-(2-hydroxyethyl)thiophene tosylate (424 mg), anhydrous sodium carbonate (265 mg) and benzyltrimethylammonium chloride (4 mg) in dry N,N-dimethylformamide (5 ml) was heated at 90° C. After 41/2 h the reaction mixture was evaporated to dryness and the residue was suspended in ethyl acetate (50 ml) and washed with water (3×15 ml), dried (MgSO4) and evaporated to a solid. The solid was subjected to p.l.c. on silica developing with chloroform-ethanol, 19:1. The more polar band was eluted with ethyl acetate and crystallised twice from acetone to give white crystals of the title pyrimidinone (94 mg), m.p. 182°-183° C., λmax (EtOH) 230 nm (ε 17,190), 335 nm (ε 3,470).

Provenance & Evidence