HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 86648479, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (3R,4S)-4-Amino-1-boc-3-methoxypiperidine | HCID 57362389 | — |
| Reactant | 4-Chloro-5-isopropylimidazole-2-carboxylic Acid | HCID 68406171 | — |
| Product | HCID 86648479 | HCID 86648479 | — |
Reaction Steps
The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1e) (0.50 g, 2.17 mmol), 4-chloro-5-(propan-2-yl)-1H-imidazole-2-carboxylic acid obtained in Example (35f) (0.30 g, 1.59 mmol), WSC hydrochloride (0.92 g, 4.80 mmol) and HOBT (0.22 g, 1.63 mmol), to obtain 0.60 g of the title compound as a white foamy substance (94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-ef6e077f7b7d487891933e0329680dde |
| Source note | uspto-grants-2013_09 |