1,1-Bis(2,2-dimethylpropoxy)-N,N-dimethylmethanamine → HCID 20491778, compound

Participants

Reaction Conditions

Reaction Steps

N,N-Dimethylformamide dineopentyl acetal (2.72 ml) was added to a stirred suspension of 5-chloropyrimidin-2-one (789 mg) and 3-hydroxymethyl-3-methylthietane (1.000 g) in dry N,N-dimethylformamide (15 ml) under nitrogen and the mixture was then heated at 100° C. After 42.5 h the reaction mixture was evaporated and the resulting black residue was dissolved in ethyl acetate (300 ml), washed with water (3×70 ml), dried (MgSO4) and evaporated to a dark brown gum. Trituration of the gum with diethyl ether gave a pale brown solid which was crystallised from ethyl acetate to give cream crystals of the title pyrimidinone (110 mg), m.p. 200°-202° C., νmax (nujol) 1663, 1510 cm-1 (C=O), 1612, 1582 cm-1 (C=C, C=N).

Provenance & Evidence