HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole → 2-Methyl-4-morpholino-5-fluoroindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole | HCID 20258982 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Methyl-4-morpholino-5-fluoroindole | HCID 20258992 | 72.4% |
Reaction Steps
Raney nickel (1.5 kg) was added to a solution of 214 g of 2-methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole in 3 l of ethanol and the mixture was refluxed for 3 hours. After completion of reaction the reaction mixture was cooled and Raney nickel was removed by filtration. Concentration of the filtrate gave 101 g of 2-methyl-4-morpholino-5-fluoroindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04399134 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-0f6a3ed58359487a834df5ef0309a4c6 |
| Source note | uspto-grants-1983_08 |