反应详情

To a solution of 24 g of 2-methyl-4-morpholino-5-fluoro-7-bromoindole in 200 ml of ethanol was added 1 g of palladium-carbon and then 15 ml of a 20% aqueous sodiium hydroxide solution. This mixture was subjected to catalytic reduction at room temperature and at atmospheric pressure. The reaction was stopped when a theoretical amount (about 1.7 l) of hydrogen was absorbed, and the catalyst was removed by filtration followed by concentration. The residue was purified through silica gel column chromatography (Wako gel C-200; eluent:chloroform:n-hexane=5:1) to give 11.8 g of 2-methyl-4-morpholino-5-fluoroindole.

1. customwas subjected to catalytic reduction at room temperature and at atmospheric pressure
2. customwas absorbed
3. customthe catalyst was removed by filtration
4. concentrationfollowed by concentration
5. customThe residue was purified through silica gel column chromatography (Wako gel C-200; eluent:chloroform:n-hexane=5:1)