Sodium Bicarbonate → HCID 13194174, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8-methoxy-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (1.75 g, 0.00696 mol) and pyridinium hydrochloride (10.5 g) is stirred at 190° for 2.5 hr. The melt is cooled to 50° C. and slurried with water (50 ml). The slurry is made basic with aqueous saturated NaHCO3 and extracted with ethyl acetate (3×50 ml). The combined extracts are dried over MgSO4 and filtered and the filtrate evaporated to dryness under reduced pressure to give 1.62 g (98%) of crude title compound. A sample recrystallized from ethyl acetate has m.p. 245°-247° C.

Provenance & Evidence