Methyl Isocyanate → HCID 135689600, compound

Participants

Reaction Steps

To a 350 milliliter glass pressure bottle equipped with a magnetic stirrer was added 5.15 grams (0.020 moles) of 4-(2,4-dihydroxybenzylideneamino)-3,5-dimethylphenol prepared in Part A, 2.40 grams (0.042 moles) of methyl isocyanate, 100 milliliters of ethyl acetate and 5 drops of dibutyltin diacetate. The resulting reaction mixture was stirred for 18 hours at room temperature, diluted with an additional 100 milliliters of ethyl acetate and washed twice with a 1% aqueous sodium bicarbonate solution followed by a single wash with saturated brine solution. After drying the reaction mixture over magnesium sulfate, it was concentrated under reduced pressure to give 7.25 grams (0.0195 moles) of 4-[2-hydroxy-4-(methylcarbamoyloxy)benzylideneamino]-3,5-dimethylphenyl methylcarbamate in the form of a yellow solid having a melting point of 70°-65° C. and the following structural formula: ##STR19##

Provenance & Evidence