HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-2-butene → 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-2-butene | HCID 10553 | — |
| Reactant | Sodium Chlorite | HCID 23668197 | — |
| Reactant | Monosodium phosphate | HCID 23672064 | — |
| Reactant | 5-Ethyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde | HCID 86648487 | — |
| Product | 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid | HCID 67548558 | 99% |
Reaction Steps
The same operation as in Example (33c) was performed using 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde obtained in Example (39d) (110 mg, 0.57 mmol), sodium chlorite (108 mg, 1.19 mmol), sodium dihydrogenphosphate (178 mg, 1.14 mmol) and 2-methyl-2-butene (0.3 mL, 2.84 mmol), to obtain 117.5 mg of the title compound as a white solid (99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-9cd2a23896944e8e8f3051454bacca09 |
| Source note | uspto-grants-2013_09 |