反应详情

To a suspension of 4.0 g. (13.7 mmole) of 2,2'-bipyridinium chlorochromate in 15 ml of dichloromethane is added, while stirring, 0.5 g. (3.5 mmole) of 2-isopropylcyclohexanol in 10 ml of dichloromethane. The resulting reaction mixture is stirred for 4 hours and then filtered through a Hirsch funnel packed with 2 cm of Celite®. The resulting clear filtrate is washed with 5% hydrochloric acid and 10% sodium carbonate, and dried over magnesium sulfate. The drying agent is then removed and the solvent evaporated to yield a colorless oil which is distilled via Kugelrohr to yield pure 2-isopropylcyclohexanone in a typical yield of 0.425 g. which is 86% of theoretical yield.

1. additionTo a suspension of 4.0 g
2. customThe resulting reaction mixture
3. stirringis stirred for 4 hours
4. filtrationfiltered through a Hirsch funnel
5. washThe resulting clear filtrate is washed with 5% hydrochloric acid and 10% sodium carbonate
6. dry with materialdried over magnesium sulfate
7. customThe drying agent is then removed
8. customthe solvent evaporated
9. customto yield a colorless oil which
10. distillationis distilled via Kugelrohr