Acetic Acid → HCID 13051490, compound

HRID 434770Notes

Reaction equation

HRID 434770 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](=[O:22])[NH:10][CH:11]=[C:12]3[C:17]=2[NH:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[S:13]3)=[CH:4][CH:3]=1.C(O)(=[O:25])C.C(OO)(=O)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9](=[O:22])[NH:10][CH:11]=[C:12]3[C:17]=2[NH:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[S:13]3=[O:25])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6585Peracetic AcidHCID 13051480HCID 13051480, compound

Product 1

HCID 13051490HCID 13051490, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 3 parts of the product of the process described in Example 14, 4-(4-chlorophenyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one, suspended in 5 parts acetic acid is added and 1 part 40% peracetic acid. After ten minutes reaction time, water is added to the now homogeneous reaction mixture and the precipitate which forms is collected and recrystallized from aqueous DMF to yield white needles of 4-(4-chlorophenyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one 10 oxide, melting above 310°.

Workup

  1. additionis added
  2. additionis added to the now homogeneous reaction mixture
  3. customthe precipitate which forms is collected
  4. customrecrystallized from aqueous DMF

Sources & evidence

ORD record
ord-98211430470944b9a777d36e600a54da
Source dataset
uspto-grants-1983_08
Patent number
US04399279

Reaction notes

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