Acetamide → HCID 178474815, compound

HRID 434778Notes

Reaction equation

HRID 434778 reaction equation
O=[C:2]([CH2:6][CH2:7][PH:8]([CH2:10][OH:11])=[O:9])[C:3]([OH:5])=[O:4].[C:12]([NH2:15])(=[O:14])[CH3:13]>O>[C:12]([NH:15][C:2](=[CH:6][CH2:7][PH:8]([CH2:10][OH:11])=[O:9])[C:3]([OH:5])=[O:4])(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 178AcetamideHCID 178525999HCID 178525999, compound

Product 1

HCID 178474815HCID 178474815, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A finely divided mixture of 2-oxo-4-(hydroxymethylphosphinyl)butanoic acid (1.80 g, 10 mmol) and acetamide (1.18 g, 20 mmol) were heated at 100° for 5 hours at 20 mm Hg. The mixture melted with evolution of water vapour. The final product was a yellow glass-like solid which was evacuated at 0.1 mm Hg at 100° for one hour to remove excess acetamide.

Workup

  1. temperaturewere heated at 100° for 5 hours at 20 mm Hg

Sources & evidence

ORD record
ord-686f37f021704e9bbb348e393d93a631
Source dataset
uspto-grants-1983_08
Patent number
US04399287

Reaction notes

Loading…