Ethylene Glycol → HCID 20492181, compound

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Reaction Steps

A mixture of N-[2-[(5-formyl-2-furanylmethyl)thio]ethyl ]-1H-isoindole-1,3-(2H)-dione (15 g), p-toluenesulphonic acid (0.12 g) and 1,2-ethanediol (6.2 g) in benzene (160 ml) was refluxed under Dean-Starke conditions. After 6 hours, the solution was washed with a solution of sodium carbonate (1.2 g) in water (25 ml), dried (Na2CO3), decolourised (charcoal) and evaporated in vacuo. The semi-solid residue was suspended in ether (200 ml) and filtered off to give the title compound (13.5 g), m.p. 83°-85°.

Provenance & Evidence