HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 4-chloro-3-oxo-2-propargyloxyiminobutyrate | HCID 53939675 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate | HCID 53907014 | 53.5% |
Reaction Steps
Ethyl 4-chloro-3-oxo-2-propargyloxyiminobutyrate (syn isomer, 61 g.), thiourea (20 g.), sodium acetate 3-hydrate (35.8 g.), water (150 ml.) and ethanol (180 ml.) were treated in a similar manner to that of Example F-(3) to give ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate (syn isomer, 35.6 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04399133 |
| Source dataset | uspto-grants-1983_08 |
| ORD ID | ord-9a544ca3453b413f84174dc81f431425 |
| Source note | uspto-grants-1983_08 |