1-Hydroxybenzotriazole → tert-Butyl cis(+/-)-4-{[(4-chloro-5-propyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	(3R,4S)-4-Amino-1-boc-3-methoxypiperidine	HCID 57362389	—
Reactant	HCID 67549025	HCID 67549025	—
Product	tert-Butyl cis(+/-)-4-{[(4-chloro-5-propyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate	HCID 86648504	—

Reaction Steps

The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1e) (0.39 g, 1.69 mmol), 4-chloro-5-propyl-1H-imidazole-2-carboxylic acid obtained in Example (46d) (0.16 g, 0.85 mmol), WSC hydrochloride (0.50 g, 2.58 mmol) and HOBT (0.12 g, 0.87 mmol), to obtain 0.32 g of the title compound as a white foamy substance (94%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08536197B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-58c96173088441d79c88bdcbb555e5b8
Source note	uspto-grants-2013_09