HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → cis(+/-)-3-(4-{[(5-Ethyl-4-trifluoromethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidin-1-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl cis(+/-)-3-(4-{[(5-Ethyl-4-trifluoromethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidin-1-yl)benzoate | HCID 86648507 | — |
| Product | cis(+/-)-3-(4-{[(5-Ethyl-4-trifluoromethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidin-1-yl)benzoic acid | HCID 86648509 | 86% |
Reaction Steps
The same operation as in Example (42f) was performed using tert-butyl cis(±)-3-(4-{[(5-ethyl-4-trifluoromethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidin-1-yl)benzoate obtained in Example (48f) (80 mg, 0.16 mmol) and trifluoroacetic acid (1 ml), to obtain 61.1 mg of the title compound (86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-f564139e9a06413380e4637df0850d8e |
| Source note | uspto-grants-2013_09 |