2-Methyl-2-butene → cis(+/-)-2-(4-{[(4-Chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-(ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid

Participants

Reaction Steps

The same operation as in Example (33c) was performed using ethyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-formyl-1,3-thiazole-5-carboxylate obtained by the method described in Example (28a) (400 mg, 0.85 mmol), sodium chlorite (158 mg, 1.75 mmol), sodium dihydrogenphosphate (410 mg, 2.63 mmol) and 2-methyl-2-butene (0.55 mL, 5.20 mmol), to obtain 439 mg of the title compound (100%).

Provenance & Evidence