N-Iodosuccinimide → ethyl 5-ethyl-4-iodo-1H-imidazole-2-carboxylate

HRID 43505Notes

Reaction equation

HRID 43505 reaction equation
[CH2:1]([C:3]1[NH:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:5][CH:4]=1)[CH3:2].C1C(=O)N([I:20])C(=O)C1>>[CH2:1]([C:3]1[NH:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:5][C:4]=1[I:20])[CH3:2]

Participants

3

Reactant 2

HCID 120273N-IodosuccinimideHCID 14990237Ethyl 5-ethyl-1H-imidazole-2-carboxylate2×

Product 1

HCID 68405791ethyl 5-ethyl-4-iodo-1H-imidazole-2-carboxylateYield 100%

Procedure

The same operation as in Example (1c) was performed using ethyl 5-ethyl-1H-imidazole-2-carboxylate obtained by the method described in Example (1b) (0.20 g, 1.19 mmol) and NIS (0.29 g, 1.31 mmol), to obtain 0.35 g of the title compound as a pale yellow solid (100%).

Workup

  1. customobtained by the method

Sources & evidence

ORD record
ord-996c4fc53a0f4e24a3049abe2e5d0e9f
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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