Acetic Anhydride → HCID 20490684, compound

HRID 435060Notes

Reaction equation

HRID 435060 reaction equation
[CH3:1][C:2]1([CH3:19])[CH:6]([OH:7])[CH2:5][C:4]([CH2:10][O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([CH2:8][CH3:9])[O:3]1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>N1C=CC=CC=1>[CH3:19][C:2]1([CH3:1])[CH:6]([O:7][C:20](=[O:22])[CH3:21])[CH2:5][C:4]([CH2:10][O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([CH2:8][CH3:9])[O:3]1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20490686HCID 20490686, compound

Product 1

HCID 20490684HCID 20490684, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The alcohol of Example 3 (800 mg) was added to pyridine (20 ml) and acetic anhydride (5 ml) and the mixture was stirred at room temperature over two days. The mixture was then evaporated down under vacuum and the residue was dissolved in diethyl ether. The solution was decolourised over charcoal, and the ether was removed to give 860 mg of the desired product. NMR showed that the product was a mixture of geometric isomers.

Workup

  1. customThe mixture was then evaporated down under vacuum
  2. dissolutionthe residue was dissolved in diethyl ether
  3. customthe ether was removed

Sources & evidence

ORD record
ord-15b4d5c3d26143e68cc332488f0be11d
Source dataset
uspto-grants-1983_08
Patent number
US04400198

Reaction notes

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